Life styles, anxiety, expertise: the perception of risk from electromagnetic fields. Brief exposures to theta-burst magnetic fields impair the consolidation of food-induced conditioned place preference. Exposure measurement errors, risk estimate and statistical power in case-control studies using dichotomous analysis of a continuous exposure variable. Nature of the changes in metabolic indices under the effect of radio waves of nonthermal intensity. Static electromagnetic fields generated by corrosion currents inhibit human osteoblast differentiation. The influence of variable and constant magnetic fields on biota and biological activity of ordinary chernozem soils. Effect of electromagnetic field accompanying the magnetic resonance imaging on human heart rate variability-a pilot study. Archives des maladies professionnelles de medecine du travail et de securite sociale. Environmental and health investigation in female workers exposed to a radiofrequency electromagnetic field. Extremely low frequency electromagnetic fields affect proliferation and mitochondrial activity of human cancer cell lines. Follow up study on the immune response to low frequency electromagnetic fields in men and women working in a museum. A simple experiment to study electromagnetic field effects: protection induced by short-term exposures to 60 Hz magnetic fields. Short-term magnetic field exposures (60 Hz) induce protection against ultraviolet radiation damage. Effects of electromagnetic radiation on implantation and intrauterine development of the rat. Effect of electromagnetic pulse exposure on brain micro vascular permeability in rats. Increase in hypoxanthine-guanine phosphoribosyl transferase gene mutations by exposure to electric field. Anxiety-like behavioural effects of extremely low-frequency electromagnetic field in rats. International trends in electromagnetic radiation bioeffects research proceedings. Influence of electromagnetic rays caused by cellular communication devices on human health (review of literature). The effect of electromagnetic radiation on the monoamine oxidase A activity in the rat brain. Recent results in cancer research Fortschritte der Krebsforschung Progres dans les recherches sur le cancer. Childhood cancer in relation to distance from high voltage power lines in England and Wales: a case-control study. Observations of changes in neurobehavioral functions in workers exposed to high-frequency radiation. Electromagnetic interference with implantable cardiac pacemakers by video capsule. Electromagnetic interference from wireless video-capsule endoscopy on implantable cardioverter-defibrillators. Hygienic standards for electromagnetic fields taking into account species traits and the time of action of the factor. Effect of a low-frequency (50 Hz) electromagnetic field on the functional state of the human body. Hygienic evaluation of the electromagnetic field created by high-voltage electric power transmission lines. Activity of enzymatic systems exposed to a superhigh-frequency electromagnetic field.
Figure 1A suggested representative proliferation inhibitory effects of gefitinib, pemetrexed and combined treatment for 48 hours. A colour standard for data normalization was shown at the bottom with green representing downregulated genes while red representing upregulated genes. Method: A total of 750 patients with non-small-cell lung cancer were recruited between July 2012 and December 2016. Method: A total of 972 patients with non-small-cell lung cancer were recruited between July 2012 and December 2016. Chemotherapy may be considered as a possible treatment for carriers of the mutation. Unfortunately, radiation resistance and local failure remain to be the major clinic problems for lung cancer patients. Western blot was performed to identify the activation of related signaling pathways. Method: A total of 851 patients with non-small-cell lung cancer were recruited between July 2012 and December 2016. Method: A total of 893 patients with nonsmall-cell lung cancer were recruited between July 2012 and December 2016. The expression of miR-320a, miR-25-3p and miR-148a-3p significantly correlated with stage, while miR-375 expression significantly correlated with lymph node involvement and pleural effusion. Method: A total of 1152 patients with non-small-cell lung cancer were recruited between July 2012 and December 2016. Because of this it is mandatory to find complementary tools to reach a more accurate classification in order to the best selection of treatments for every patient. Blood samples were obtained at least at three different moments: before surgery (S1), one year after the operation (S2) and the last one 2 years after the operation (S3). And adenocarcinoma accounts for the majority of all Non-small cell lung cancer cases. Increasing evidences indicate a relationship between inflammation and lung carcinogenesis. The present study was performed to evaluated the value of inflammation biomarker in predicting the prognosis of early stage lung adenocarcinoma. Result: A total of 152 early stage lung adenocarcinoma patients were analyzed in this study. Results of ongoing studies will provide a platform for further research to offer individualized therapy with the purpose of improving outcomes. Method: A total of 526 patients with non-small-cell lung cancer were recruited between July 2012 and December 2016. Inflammation plays a critical role in the development and progression of various cancers by promoting cancer cell proliferation and survival, angiogenesis and tumor metastases. Inflammatory cells in the tumor microenvironment significantly affect tumor development, and markers of systemic inflammation may indicate tumor status. These markers are based on two or three parameters selected among neutrophils, lymphocytes, platelets and monocytes. We aimed to explore genes that are implicated in the process of brain metastasis of primary lung adenocarcinoma. All tumors were analyzed with the NanoString nCounter system for gene expression using the nCounter PanCancer Progression panel composed of 740 genes. Conclusion: Although our findings are not conclusive, we have identified differentially expressed genes that might mediate the brain metastasis process. Method: A total of 730 patients with non-small-cell lung cancer were recruited between July 2012 and December 2016. Statistical analyses were performed with the use of: Shapiro-Wilk test, T-test Wilcoxon matched pairs singed-rank test and Mann-Whitney U test. As most precision medicines lead to resistance, the challenge of identifying new targets for further effective therapies still remains.
Interaction of static and extremely low frequency electric and magnetic fields with living systems: health effects and research needs. A case-control pilot study of traffic exposures and early childhood leukemia using a geographic information system. Structural evaluation of porcine heart valve prostheses with radiofrequency ultrasound. Cardiovascular pathology: the official journal of the Society for Cardiovascular Pathology. Cerebrovascular accident after percutaneous rf thermocoagulation of the trigeminal ganglion. Percutaneous Selective Neuromodulation via Monopolar Radiofrequency for Glabellar Lines: A Case Study. Birth defects and high voltage power lines: an exploratory study based on registry data. The biological effects of radiofrequency radiation: a critical review and recommendations. Lowfrequency pulsed electromagnetic field exposure can alter neuroprocessing in humans. The effect of electromagnetic fields on living organisms: plants, birds and animals. Responses of the estrous cycle in dairy cows exposed to electric and magnetic fields (60 Hz) during 8-h photoperiods. Strategies in approaches to requirements in the control of electromagnetic irradiation levels. Colorectal disease: the official journal of the Association of Coloproctology of Great Britain and Ireland. Cardiovascular mortality and exposure to extremely low frequency magnetic fields: a cohort study of Swiss railway workers. Conduct of a personal radiofrequency electromagnetic field measurement study: proposed study protocol. Systematic review on the health effects of exposure to radiofrequency electromagnetic fields from mobile phone base stations. Commentary: magnetic field exposure and childhood leukaemia-moving the research agenda forward. Leukaemia, brain tumours and exposure to extremely low frequency magnetic fields: cohort study of Swiss railway employees. Mortality from neurodegenerative disease and exposure to extremely lowfrequency magnetic fields: 31 years of observations on Swiss railway employees. Annales de readaptation et de medecine physique: revue scientifique de la Societe francaise de reeducation fonctionnelle de readaptation et de medecine physique. Evaluation of the local effect of the magnetic field on the human body in laboratory studies. Effect of mobile phones on micronucleus frequency in human exfoliated oral mucosal cells. Extremely low frequency electromagnetic fields prevent chemotherapy induced myelotoxicity. Do people with idiopathic environmental intolerance attributed to electromagnetic fields display physiological effects when exposed to electromagnetic fields? Analysis of electromagnetic absorption in biologic objects with industrial high-frequency heating of dielectric materials. The evaluation of the consequences of electromagnetic irradiation of hands in operators of high-frequency welding devices. Letter to the editor: doubts raised about the blinding process do not apply to the Diem et al. Evaluation of the developmental toxicity of 60 Hz magnetic fields and harmonic frequencies in Sprague-Dawley rats. Early ultrastructural reactions in various parts of the visual analyzer in guinea pigs after thermogenic microwave irradiation.
The first is improving the selection of at-risk subjects to be screened, and the second is to guide the management of screening detected pulmonary nodules. Biomarkers of lung cancer risk can include a variety of potential biospecimens, ranging from sputum and exhaled breath condensates to endobronchial and peripheral lung biopsies. While sputum cytology can also predict the presence of pre-malignant central airway lesions, sputum collection has largely fallen out of favor due to perceived difficulties in collecting and interpreting specimens, and advances in analyzing other specimens like blood, urine and exhaled breath. Sputum is a readily available resource, and recent methodological advances, most notably automated 3-dimensional morphologic analysis of sputum3, are currently being studied to determine the presence of cancer or pre-malignant lesions. For example, selected gene promoter methylation in exfoliated cells from sputum has been shown to predict cancer up to 18 months prior to diagnosis4. More recently, a pilot study using metagenetic sequencing of the sputum microbiome suggests there may be bacterial biomarkers indicating the presence of lung cancer6. Exhaled breath condensate is an additional biospecimen that has been studied as an adjunct to screening protocols, and the subject is extensively reviewed in a recent publication7. This will allow for a better understanding of progressive lesions and advance the field of precision chemoprevention. Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Automated 3-dimensional morphologic analysis of sputum specimens for lung cancer detection: Performance characteristics support use in lung cancer screening. Defining a gene promoter methylation signature in sputum for lung cancer risk assessment. A pilot study using metagenomic sequencing of the sputum microbiome suggests potential bacterial biomarkers for lung cancer. Persistence of Bronchial Dysplasia Is Associated with Development of Invasive Squamous Cell Carcinoma. Successful smoking interventions have the potential to greatly reduce morbidity and mortality in lung cancer screenees. It is likely that smoking cessation interventions in lung cancer screening programs will be costeffective and may lead to health benefits that exceed those of the lung cancer mortality reduction benefits. However, which type of smoking cessation program in the lung cancer screening setting is most effective is unknown. Lung cancer screenees generally have longer and more intense smoking histories so they may be more intractable to cessation interventions. On the other hand, screening may provide a teachable moment, which may lead to greater rates of cessation. Two recent reviews concluded that evidence is lacking to recommend specific tailored smoking cessation approach in the lung cancer screening setting and recommend more research. In conclusion, several intervention approaches appear to be associated with smoking cessation. The health consequences of smoking-50 years of progress:a report of the Surgeon General. Smoking cessation interventions within the context of Low-Dose Computed Tomography lung cancer screening: A systematic review. Systematic Review and Meta-Analysis of Smoking Cessation Interventions for Potential Use in Lung Cancer Screening Settings: 6- and 12-Month Outcomes. The delightful changing recently is some studies emerging to consider the characteristics of the Chinese or Asian populations. Treatment patterns of lung cancer has been transformed over the years, leading to the better outcomes of patients. Furthermore, among the total Asian population, Chinese has the highest percentage of adenocarcinomas (69. There has evidence that different population has different sensitivity and toxicity to different anti-tumor regiments. In a word, ethnic difference can influence efficacy and toxicity of different treatment options. More genomic mapping and preclinical research should be implemented to explore the relationship between ethnic diversity and varying degrees of response.
Radiation, work experience, and cause specific mortality among workers at an energy research laboratory. Radiation doses and cause-specific mortality among workers at a nuclear materials fabrication plant. Suppression of apoptosis by Bcl-2 or Bcl-xL promotes susceptibility to mutagenesis. The effect of a change in mutation rate on the incidence of dominant and X-linked recessive disorders in man. Microsatellite analysis of recurrent chromosome 2 deletions in acute myeloid leukaemia induced by radiation in F1 hybrid mice. Comments on the evidence in support of the epigenetic nature of radiogenic initiation. Differentiation and delayed cell death in embryonal stem cells exposed to low doses of ionising radiation. Radiation-induced genomic instability and persisting oxidative stress in primary bone marrow cultures. Effects of radiation on incidence of primary liver cancer among atomic bomb survivors. Review of Medical Findings in a Marshallese Population Twenty-Six Years after Accidental Exposure to Radioactive Fallout. A quantitative comparison of potentially lethal damage repair and the rejoining of interphase chromosome breaks in low passage normal human fibroblasts. Dose responses for chromosome aberrations produced in noncycling primary human fibroblasts by alpha particles and by gamma rays delivered at sublimiting low dose rates. Comments on the paper: Microsatellite instability in acute myelocytic leukaemia developed from A-bomb survivors-and related cytogenic data. Inactivation and mutation of cultured mammalian cells by aluminium characteristic ultrasoft x-rays. Mortality among Workers at a Nuclear Fuels Production Facility: the Savannah River Site, 1952-1986. Inverse dose-rate effect for the induction of 6-thioguanine-resistant mutants in Chinese hamster V79-S cells by 60Co gamma rays. Relationship of leukemia risk to radiation dose following cancer of the uterine corpus. Congenital anomalies: estimates of detriment in terms of years of life lost and years of impaired life. Some selected common multifactorial diseases: estimates of detriment in terms of years lost and impaired life. A cohort study with regard to the risk of haematological malignancies in patients treated with x-rays for benign lesions in the locomotor system. Mortality from cardiovascular disease more than 10 years after radiotherapy for breast cancer: nationwide cohort study of 90,000 Swedish women. Thyroid neoplasia, autoimmune thyroiditis, and hypothyroidism in persons exposed to I-131 from the Hanford Nuclear Site. Risk of thyroid cancer in the Bryansk Oblast of the Russian Federation after the Chernobyl Power Station accident. Recombination involving interstitial telomere repeat-like sequences promotes chromosomal instability in Chinese hamster cells. Role of radiotherapy and chemotherapy in the risk of second malignant neoplasms after cancer in childhood. Second malignant neoplasms after a first cancer in childhood: temporal pattern of risk according to type of treatment. Cancer mortality among atomic bomb survivors exposed in utero or as young children, October 1950-May 1992. The concept of mutation component and its use in risk estimation for multifactorial diseases. Radiation-induced release of transforming growth factor alpha activates the epidermal growth factor receptor and mitogen-activated protein kinase pathway in carcinoma cells, leading to increased proliferation and protection from radiation-induced cell death. Comparisons of tritiated thymidine, tritiated water, and cobalt-60 gamma rays in inducing chromosomal aberrations. Comparison of lethality and chromosomal damage induced by x-rays in synchronized Chinese hamster cells in vitro.
Furthermore, the small increases in thyroid cancer observed in some studies are likely due to the underlying thyroid condition, not to radiation exposure. No excess risk of thyroid cancer was found in residents exposed to radiation from Hanford, and the slight excess risk of thyroid neoplasms associated with radioiodine exposure of Utah residents from the Nevada Test Site was based on small numbers. In contrast, substantial increases in thyroid cancer have been reported in areas contaminated with radioactive fallout Copyright National Academy of Sciences. Notably, most of the studies do not specify the nature of the radiation exposure, and none of the 16 contain individual estimates of radiation dose. Although some of these studies report an increased occurrence of cancer that could be related potentially to environmental radiation exposures, none provide a direct quantitative estimate of risk in relation to radiation dose. There have been three case-control studies of persons living around a nuclear facility. One focuses on congenital and perinatal conditions, stillbirths, and infant deaths in relation to exposure from uranium mines. Neither study found an increased risk associated with parental radiation exposure and X-ray exposure of the child, but both did find an increased risk associated with playing on beaches near the nuclear facility. Results from studies of residents living near the Techa River have found no evidence of a decrease in birth rate or fertility in the exposed population and no increased incidence of spontaneous abortions or stillbirths. There is some evidence of a statistically significant increase in total cancer mortality. Estimates of the relative risk for cancer of the esophagus, stomach, and lung are similar to those reported for atomic bomb survivors. There is no evidence of an increase in cancer mortality in the offspring of exposed residents. The one study of persons living in the town of Ozyorsk exposed to fallout from the nearby Mayak nuclear facility reported an excess of thyroid cancer three to four times that expected relative to rates for all of Russia and a somewhat lower excess (1. A follow-up study of persons exposed as young children to atmospheric releases primarily of 131I from the Hanford from Chernobyl, primarily among children. Although much of the thyroid dose from Chernobyl is due to 131I, exposure to a mix of other radionuclides and the lack of individual dose estimates in most of the studies to date have made it difficult to develop quantitative risk estimates for radiation dose from 131I. However, there is now emerging evidence indicating that exposure to radiation from Chernobyl is associated with an increased risk of thyroid cancer and that the relationship is dose dependent. These findings are based on individual estimates of thyroid radiation dose and reveal strong and statistically significant dose-related increased risks that are consistent across studies. Thus, although the precise quantitative relationship between radiation dose from 131I and the development of thyroid neoplasia remains uncertain at this time, recent findings from studies around Chernobyl and Hanford provide important quantitative estimates of risk as a function of dose. Such studies are limited in their usefulness in defining risk of disease in relation to radiation exposure or dose. They can sometimes be informative in generating new hypotheses or suggesting directions for study, but seldom, if ever, are they of value in testing specific hypotheses or providing quantitative estimates of risk in relation to specific sources of environmental radiation. Fewer attempts have been made to evaluate the effect of environmental radiation exposures using the two most common analytical study designs employed in epidemiology: the case-control study and the cohort study. Such studies are almost always based on individual-level data and thus are not subject to many of the limitations inherent in ecologic studies. They can potentially provide quantitative estimates of risk based on individual radiation dose. Unfortunately, the published literature on environmental radiation exposures is not characterized by studies with such features. Sixteen ecologic studies of populations living around nuclear facilities are summarized, thirteen of the locations Copyright National Academy of Sciences. Numerous epidemiologic studies have been carried out since the Chernobyl accident to investigate the potential late health consequences of exposure to ionizing radiation from the accident. Most reports are descriptive incidence and prevalence studies that utilize population or aggregate estimates of radiation dose. Only three analytical studies are published that report dose-response results based on individual dose estimates.
Particularly, in pts treated with immunotherapy, muscle mass wasting seems to impact on efficacy outcome, suggesting a potential interaction between immunological and nutritional parameters. Changes in psoas muscles observed in subsequent scans were evaluated using Wilcoxon signed-rank test. Conclusion: Compared to data collected in 2012, five of six implicit and explicit attitudes showed a significant reduction in negativity toward lung cancer relative to breast cancer. Improvements in lung cancer survival rates are not comparable with improvements for other cancers. A linked implementation science program will identify methods to promote better integration of research findings and evidence. Design Prospective clinical cohort of lung cancer patients including matched demographic, clinical, biomarker, molecular profile, and outcome data (including quality of care and patient-reported outcomes) for current and future research projects. Exclusion criteria included: major surgery or radiation therapy three months before treatment, chemotherapy or other therapy as first-line treatment, a second active cancer, or a cognition or sensory issue. Trained qualitative interviewers used a semi-structured interview guide, and conducted all interviews by telephone. Ratings of severity and bothersomeness trended toward the mid-range of the scale (4. The higher ratings were seen for very specific symptoms reported by only one or two patients, including constipation (8. Clinicians should also consider these when assisting patients in managing their symptoms. In this study, we aimed to assess the clinicopathologic outcome of resected lung cancer in each group. In order to identify the site of such lesions, various types of preoperative or intraoperative marking methods have been reported. Therefore, we have reported a new safe and reliable intraoperative marking method using low power laser light. By irradiating low power laser close to the lesion from a bronchus, the site of the lesion can be identified from the lung surface by looking at the laser light. We conducted an animal experiment and were able to observe the laser light irradiated in bronchus from the lung surface. In this study, we performed laser irradiation to the resected human lung to confirm whether the laser light can actually be observed safely from lung surface. Immediately after right upper lobectomy, a plastic cylindrical-type laser probe was inserted into peripheral bronchus of the resected lung. The probe was induced just below the pleura and 70mW low power laser irradiation was performed. Result: When the probe was guided to just below the pleura, laser light could be clearly observed from the lung surface. The reasons of this were guessed that lung expansion was not sufficiently because harvested lung was used, so the density of lung tissue was increase and pleural thickening and anthracosis were observed in the lung because of his smoking history. Conclusion: It might be possible to confirm the localization of small nodules in peripheral lung using low power laser light during surgery. Continuous and categorical variables were compared by nonparametric methods with Spearman and Kruskal-Wallis tests. Result: 14 patients who completed treatment as prescribed, with 17 total target lesions, were included. Recently, there is a growing concern that those who participated in clinical trials are highly selected and do not represent the "real-world" population. We compared several clinicopathological factors and the long-term outcome between the two groups. We performed propensity score matching analysis to minimize differences in the patient background and tumor states. Using propensity score matching, we extracted 190 patients each from the two groups.
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